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机体免疫系统的功能状态是影响乳腺癌发生和发展的一个重要因素,受复杂精确的调节网络所控制,该网络任何环节发生异常都会使正常免疫调节失去平衡,影响其功能的发挥。免疫调节基因决定了各种免疫调节因子的数量和质量,因此在免疫调节中发挥了关键作用。在基因组中,由核苷酸水平上的差异引起的 DNA 序列多态性称为单核苷酸多态性(SNP),它们构成了人类遗传变异的主要部分。乳腺癌相关的免疫调节基因的单核苷酸多态性及单体型研究成为近年来国外研究的热点之一,研究表明,免疫调节基因的多态性在调节乳腺癌患者的免疫功能方面起着重要作用,影响乳腺癌的治疗和预后。
The functional status of the immune system is an important factor affecting the occurrence and development of breast cancer. It is controlled by a complex and accurate regulatory network. Any abnormality in the network will unbalance normal immune regulation and affect its function. Immunoregulatory genes determine the quantity and quality of various immunomodulatory factors and therefore play a key role in immune regulation. In the genome, DNA sequence polymorphisms caused by differences in nucleotide levels are called single nucleotide polymorphisms (SNPs) and constitute the major part of human genetic variation. Single nucleotide polymorphisms and haplotypes of breast cancer-related immunoregulatory genes have become one of the hot spots in foreign countries in recent years. Studies have shown that the polymorphisms of immunoregulatory genes play an important role in regulating the immune function of breast cancer patients Plays an important role in the treatment and prognosis of breast cancer.