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目的观察一笑散在临床防治直肠放射性损伤方面的效果。方法将90例直肠癌保肛术术后放疗患者随机分成2组,1组为中药加放疗组(观察组),46例,另1组为单纯放疗组(对照组),44例。两组外照射2.0Gy/次,5次/周,5周完成,总剂量50 Gy。观察组从放疗始第1天至放疗结束每周2次一笑散+0.9%生理盐水100 mL,保留灌肠。比较2组直肠放射性损伤发生情况。结果放疗1年后行纤维结肠镜检查结果显示,观察组共15例发生直肠放射性损伤,其中Ⅰ度为10例,Ⅱ度为3例,Ⅲ度为2例;对照组共发生44例,Ⅰ度为21例,Ⅱ度为14例,Ⅲ度为9例。两组比较差异有显著性意义(P<0.01)。结论中药一笑散对防治直肠放射性损伤有显著性疗效。
Objective To observe the effect of a smile scattered in the prevention and treatment of rectal radiation injury. Methods Ninety cases of rectal cancer after anal sphincter-preserving surgery were randomly divided into two groups. One group was treated with traditional Chinese medicine plus radiotherapy (observation group), 46 patients were treated with radiotherapy alone, and the other was radiotherapy alone (control group). Two groups of external irradiation 2.0Gy / time, 5 times / week, 5 weeks to complete the total dose of 50 Gy. Observation group from the first day of radiotherapy to the end of radiotherapy once a week, 2 times a smile + 0.9% saline 100 mL, retention enema. The incidence of rectal radiation injury was compared between the two groups. Results One year after radiotherapy, colonoscopy showed that 15 cases had rectal radioactive injury in the observation group, of which 10 cases were grade I, 3 cases were grade II, and 2 were grade III. There were 44 cases in control group, Degree was 21 cases, Ⅱ degree was 14 cases, Ⅲ degree was 9 cases. There was significant difference between the two groups (P <0.01). Conclusion Chinese medicine Yi Xiaosan has a significant effect on the prevention and treatment of rectal radiation injury.