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目的 明确苯丁酸氮芥能否有效治疗肾病综合征 (NS) ,及最佳治疗方案 ,为临床NS治疗方案的选择提供指导。方法 通过Medline计算机检索系统检索 1 970～ 2 0 0 0年的相关文献 ,采用加权百分率法进行荟萃分析。结果 应用苯丁酸氮芥治疗的有效率 (67.0 0 % )较不含免疫抑制剂的其他治疗方案 (31 .84% )高 (P<0 .0 5) ;但应用较大剂量苯丁酸氮芥治疗 (63 .63 % )与应用较小剂量治疗 (71 .43 % )的有效率之间无明显差别(P >0 .0 5)。结论 苯丁酸氮芥能有效治疗NS且以小剂量效果较好
Objective To determine whether chlorambucil can effectively treat nephrotic syndrome (NS) and to provide the best treatment for the selection of clinical NS regimen. Methods Medline computerized retrieval system was used to search the related literature from 1970 to 2000, and the weighted percentage method was used for meta-analysis. Results The effective rate of chlorambucil (67.0%) was higher than that of other regimens without immunosuppressive agents (31.84%) (P <0.05). However, higher doses of phenylbutyrate There was no significant difference (P> 0.05) between the effective rate of nitrogen mustard treatment (63.63%) and the application of smaller dose treatment (71.43%). Conclusion Chlorambucil can effectively treat NS with good effect in low dose