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目的:通过HEPC基因SNP/A2032G多态性与有氧耐力训练后左心室功能指标训练敏感性的关联性分析,从HEPC基因中筛选预测有氧耐力训练效果的分子标记,为制定个性化有氧耐力训练方案提供科学依据。方法:对102名中国北方平原地区健康男子进行为期18周的有氧耐力训练,使用超声心动仪测定其训练前后安静状态和递增负荷运动下的左心室功能指标,应用PCR-RFLP技术解析受试者SNP/A2032G多态性。采用association studies with training response phenotypes方法分析SNP/A2032G多态性与训练前后左心室功能指标的关联性。结果:经18周有氧耐力训练后,AG型150W/SV、150W/SVI和150W/EF的训练敏感性最高。其中,AG型群体的150W/SV、150W/SVI增加量显著高于GG型,且存在高于AA型的趋势;AG型群体的150W/EF增加量显著高于GG和AA型。结论:HEPC基因SNP/A2032G的AG型可作为预测有氧耐力训练后心室功能指标训练敏感性的分子标记。
OBJECTIVE: To screen molecular markers predicting aerobic endurance training from HEPC gene by analyzing the association between SNP / A2032G polymorphism of HEPC gene and training sensitivity of left ventricular function after aerobic endurance training. To develop personalized aerobic Endurance training programs provide a scientific basis. Methods: A total of 102 healthy men in the northern plains of China were trained for aerobic endurance training for 18 weeks. The left ventricular function was measured by echocardiography before and after training. The left ventricular function was measured by PCR-RFLP SNP / A2032G polymorphism. Association study with training response phenotypes was used to analyze the association between SNP / A2032G polymorphism and left ventricular function before and after training. RESULTS: After 18 weeks of aerobic endurance training, the training sensitivities of AG models 150W / SV, 150W / SVI and 150W / EF were the highest. Among them, the increase of 150W / SV and 150W / SVI of AG population was significantly higher than that of GG and higher than that of AA. The increase of 150W / EF of AG population was significantly higher than that of GG and AA. Conclusion: The AG genotype of HEPC gene SNP / A2032G can be used as a molecular marker to predict the training sensitivity of ventricular function after aerobic endurance training.