赤芍总苷对失血性休克大鼠血流动力学影响

来源 :中国临床药理学杂志 | 被引量 : 0次 | 上传用户:zzzkkk
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的研究赤芍总苷(TSP)对失血性休克大鼠血流动力学的影响。方法用Wistar大鼠雌雄各半共24只,按照随机数字法分为4组:正常组、模型组、空白组和实验组,每组6只。4组大鼠麻醉后,都静脉注射肝素钠(2 mL·kg~(-1))全身抗凝,颈动脉插管放血,血压稳定30 min后,模型组、空白组和实验组放血至血压33.9 mm Hg,造成失血性休克模型。10 mL·kg~(-1)TSP用生理盐水配成0.5%的浓度后静脉给药,空白组给予等量的生理盐水。用生物信号采集分析系统观察大鼠的血压与心率,用自动血流变测试仪检测全血黏度、血浆黏度,红细胞变形指数、红细胞聚集指数、红细胞压积、全血还原黏度、全血相对黏度及血小板黏附率,观察TSP对失血性休克转归时血流动力学的调节作用。结果给与TSP后,实验组的全血黏度:200/s为(5.22±0.24)m Pa·s,30/s为(7.20±0.41)m Pa·s,5/s为(13.55±0.10)m Pa·s,1/s为(32.95±2.25)m Pa·s;血小板黏附率为(38.47±0.16)%,明显低于空白组的全血黏度:200/s(5.87±0.18)m Pa·s,30/s(8.46±0.23)m Pa·s,5/s(16.47±0.75)m Pa·s,1/s(41.77±1.61)m Pa·s和血小板黏附率为(39.08±0.24)%,差异有统计学意义(均P<0.05)。实验组的红细胞变形指数为0.79±0.01,明显高于空白组的0.71±0.02,差异有统计学意义(P<0.05),说明给药后红细胞变形能力明显增强。与休克时对比,用TSP复苏后,大鼠的收缩压为(106.00±13.24)mm Hg,舒张压为(76.99±13.41)mm Hg,平均血压为(80.33±8.82)mm Hg,差异有统计学意义(P<0.05)。结论 TSP能明显改善失血性休克时的血流动力学异常。 Objective To study the effects of total paeony glycoside (TSP) on hemodynamics in hemorrhagic shock rats. Methods Twenty-four male and female Wistar rats were randomly divided into 4 groups according to random number method: normal group, model group, blank group and experimental group, 6 in each group. After anesthesia, the rats in both groups were given intravenous heparin sodium (2 mL · kg -1) for systemic anticoagulation and carotid artery cannulation to exsanguinate blood. After the blood pressure was stabilized for 30 min, the model group, the blank group and the experimental group were given blood pressure to blood pressure 33.9 mm Hg, resulting in a hemorrhagic shock model. TSP 10 mL · kg -1 was dosed intravenously with 0.5% saline, while the blank group was given the same amount of saline. Blood pressure and heart rate were measured by biological signal acquisition and analysis system. Whole blood viscosity, plasma viscosity, erythrocyte deformability index, erythrocyte aggregation index, hematocrit, whole blood reduced viscosity, whole blood relative viscosity And platelet adhesion rate were observed TSP hemorrhagic shock hemodynamic outcome of the regulatory role. Results After the administration of TSP, the whole blood viscosity of the experimental group was (5.22 ± 0.24) mPa · s, (30 ± s) was (7.20 ± 0.41) m Pa · s, and that of the experimental group was (13.55 ± 0.10) mPa · s, 1 / s was (32.95 ± 2.25) mPa · s, and the rate of platelet adhesion was (38.47 ± 0.16)%, which was significantly lower than that of the blank group: 200 / s · S, 30 / s (8.46 ± 0.23) mPa · s, 5 / s (16.47 ± 0.75) mPa · s, 1 / s (41.77 ± 1.61) mPa · s and platelet adhesion rate (39.08 ± 0.24 )%, The difference was statistically significant (all P <0.05). The erythrocyte deformability index of the experimental group was 0.79 ± 0.01, which was significantly higher than that of the blank group (0.71 ± 0.02, P <0.05), indicating that the erythrocyte deformability was significantly increased after administration. Compared with the shock, the systolic blood pressure of rats was (106.00 ± 13.24) mm Hg, diastolic blood pressure was (76.99 ± 13.41) mm Hg, mean blood pressure was (80.33 ± 8.82) mm Hg after TSP resuscitation, the difference was statistically significant Significance (P <0.05). Conclusion TSP can significantly improve hemodynamic abnormality in hemorrhagic shock.
其他文献
本文通过对云南省经济责任审计现状的分析,认为经济责任审计存在滞后性、审计质量不高、审计力量和审计经费严重不足、领导干部经济责任评价难等问题,提出了完善经济责任审计
研究一种基于MPCA的多传感器故障诊断方法.这种方法把过程测量空间分为主元子空间和残差子空间.在残差子空间,首先用Q统计指标检测出传感器是否存在故障,如果Q统计指标超限,
2007年5月,国家教育部、体育总局在修改和完善2005年颁布的《《学生体质健康标准》(试行方案)》的基础上,颁布并实施了《国家学生体质健康标准》(以下简称《标准》)。本《标准》是
数据校正即是从测量的过程数据中消除过失误差并降低随机误差对测量值的影响,这对过程控制是非常重要的.采用移动中值滤波器(MM)消除过失误差,然后应用小波变换滤除随机误差.
羌塘盆地位于青藏高原的中部,是中国油气勘探程度最低的海相盆地之一,也是我国在特提斯域内最具潜力的油气勘探目标。侏罗系具有良好的生烃潜力,但是本地区储集层物性整体偏低,明
非线性光学显微成像是基于光学非线性效应产生的信号对比机制对微观物体进行成像的显微方法。该方法具有化学组分选择性,能对特定的分子、化学键进行高衬度成像。非线性过程
目的:通过对感染兔人工股骨头清创术后间隔不同时间行二期翻修术,选择感染兔人工股骨头二期翻修术的最佳时机,为临床治疗提供实验基础和理论依据。方法:取健康成年日本大耳白兔96
随着用电信息采集系统的健全,双向互动化功能的需求增加,系统所承载的用电信息由最初的规整结构化数据演变成结构化数据和多类型非结构化数据的混杂,且数据量也日益聚增。本
肺癌(Lung cancer)是世界上发病率和致死率最高的肿瘤。在我国肺癌每年发病人数超过100万,并以每年递增26.9%的速度迅速增长,但是患者的5年生存率不到15%,因此肺癌已经取代肝
<正>【活动理念】马斯洛认为人的需要从低到高依次为生理需要、安全需要、归属和爱的需要、尊重和自尊的需要以及自我实现的需要,只有实现低级需要才能满足高级需要。中学阶