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目的探讨细胞周期素D1(Cyclin D1)在胃癌表达及其与肿瘤生物学行为的关系。方法应用免疫组化法检测50例胃癌组织、10例正常胃组织、20例胃腺瘤标本中细胞周期素D1在胃癌中的表达。结果胃癌CyclinD1的异常表达率(72.0%)高于胃腺瘤60.0%),CyclinD1的表达异常与胃癌的分化程度相关,而与胃癌的浸润、转移无相关性。结论CyclinD1的激活而引起细胞增殖和分化失控。CyclinD1可作为反映胃癌生物学行为的指标。目的探讨细胞周期素D1(CyclinD1)在胃癌表达及其与肿瘤生物学行为的关系。方法应用免疫组化法检测50例胃癌组织、10例正常胃组织、20例胃腺瘤标本中细胞周期素D1在胃癌中的表达。结果胃癌CyclinD1的异常表达率(72.0%)高于胃腺瘤60.0%),CyclinD1的表达异常与胃癌的分化程度相关,而与胃癌的浸润、转移无相关性。结论CyclinD1的激活而引起细胞增殖和分化失控。CyclinD1可作为反映胃癌生物学行为的指标。
Objective To investigate the expression of Cyclin D1 in gastric cancer and its relationship with the biological behavior of tumor. Methods Immunohistochemistry was used to detect the expression of cyclin D1 in gastric carcinoma in 50 specimens of gastric carcinoma, 10 specimens of normal gastric tissue and 20 specimens of gastric adenoma. Results The abnormal expression rate of CyclinD1 in gastric cancer (72.0%) was higher than that in gastric adenoma (60.0%). The abnormal expression of CyclinD1 was correlated with the differentiation degree of gastric cancer, but not with the invasion and metastasis of gastric cancer. Conclusion Activation of CyclinD1 causes uncontrolled cell proliferation and differentiation. CyclinD1 can be used as an indicator of gastric cancer biological behavior. Objective To investigate the expression of CyclinD1 in gastric cancer and its relationship with the biological behavior of tumor. Methods Immunohistochemistry was used to detect the expression of cyclin D1 in gastric carcinoma in 50 specimens of gastric carcinoma, 10 specimens of normal gastric tissue and 20 specimens of gastric adenoma. Results The abnormal expression rate of CyclinD1 in gastric cancer (72.0%) was higher than that in gastric adenoma (60.0%). The abnormal expression of CyclinD1 was correlated with the differentiation degree of gastric cancer, but not with the invasion and metastasis of gastric cancer. Conclusion Activation of CyclinD1 causes uncontrolled cell proliferation and differentiation. CyclinD1 can be used as an indicator of gastric cancer biological behavior.