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固体分散技术已用于减小药物粒度、提高药物的溶出及吸收速率。强的松龙难溶于水,曾用水溶性载体将它制成固态分散体系。本文目的是确定PEG、PVP、尿素、山梨醇、甘露醇和cremophor等能否作为固态分散体系的载体,以及这些载体的量和化学结构对药物溶出速率的影响。试验样品包括10%药物与90%载体的固态分散体或物理混合物。PEG、尿素用熔融法、PVP用溶剂法形成固态分散体。用循环法测定样品的溶出速率。
Solid dispersion technology has been used to reduce drug particle size and improve drug dissolution and absorption rate. Prednisolone is poorly soluble in water and has been made into a solid dispersion using a water-soluble carrier. The purpose of this paper is to determine whether PEG, PVP, urea, sorbitol, mannitol and cremophor can be used as carriers for solid dispersion systems and the effect of the amount and chemical structure of these carriers on drug dissolution rates. The test sample consisted of a solid dispersion or physical mixture of 10% drug and 90% carrier. PEG, urea melt method, PVP solvent method to form a solid dispersion. Circulation method was used to determine the dissolution rate of the sample.