论文部分内容阅读
以钙基蒙脱土为原料,采用微波-力化学法制备钠基蒙脱土(MMT)。采用溶液离子交换法制备盐酸西替利嗪(CTH/MMT)纳米复合物,研究了MMT对CTH的吸附规律。利用XRD、FTIR、TG等分析了CTH/MMT复合物的结构。通过体外人工模拟胃、肠液中的释放实验表征了CTH/MMT的缓释效果、缓释机制及其动力学。结果表明,CTH插层于MMT层间,层间距由1.25 nm增至2.13 nm。MMT对CTH插层吸附等温线符合Freundlich吸附等温方程,其吸附动力学符合二级动力学方程。体外的缓释试验表明,CTH/MMT具有良好的缓释效果,MMT可作为盐酸西替利嗪的控释载体材料。
Using calcium-based montmorillonite as raw material, sodium montmorillonite (MMT) was prepared by microwave-force chemical method. The CTH / MMT nanocomposite was prepared by solution ion exchange method and the adsorption of CTH by MMT was studied. The structure of CTH / MMT complex was analyzed by XRD, FTIR and TG. The sustained-release effect, sustained-release mechanism and kinetics of CTH / MMT were characterized by in vitro simulated gastric and intestinal fluid release experiments. The results showed that CTH intercalated between MMT layers increased the distance from 1.25 nm to 2.13 nm. The adsorption isotherm of MMT on CTH accords with the Freundlich adsorption isotherm equation, and its adsorption kinetics follows the second-order kinetic equation. In vitro sustained release test showed that CTH / MMT has a good sustained-release effect, and MMT can be used as a controlled release carrier material of cetirizine hydrochloride.