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病毒性肝炎抗病毒药物的开发和评价中的重要环节之一就是建立一种方便有效的体内外模型。现就乙型肝炎的感染模型新进展作一简要综述。 一、体外模型 乙型肝炎病毒(hepatitis B virus,HBV)感染有高度的种属和组织特异性,它只感染人和类人猿。其原因是病毒黏附以及病毒DNA转录及复制对细胞有严格的要求。体外培养的
An important part of the development and evaluation of viral hepatitis antiviral drugs is to establish a convenient and effective model in vitro and in vivo. A brief overview of recent advances in hepatitis B infection models is provided. In vitro models Hepatitis B virus (HBV) infection is highly species and tissue specific and infects only humans and apes. The reason is the virus adhesion and viral DNA transcription and replication of the cells have strict requirements. Cultured in vitro