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目的分析血清乙肝病毒大蛋白在HBeAg阴性与低水平HBV-DNA乙肝患者中的检测意义。方法方便选取该院2015年5—12月期间收治的150例乙肝患者以及150名参与体检的健康群众作为该次实验的研究对象,根据其病情性质的差异,将参与实验的成员分为2个不同的组别,乙肝患者为对研究组,健康群众为对照组,平均每个小组的成员均为150例,对两组成员均采取酶联免疫吸附的试验,对其检测指标的差异进行观察与分析。结果通过比较得知,HBV-LP浓度与HBV-DNA拷贝数存在着正相关的联系,其浓度随着其拷贝数的提高而增加,HBV-DNA拷贝数<103,其HBV-LP浓度为9.82,DNA拷贝数为103~105,其HBV-LP浓度为15.43,DNA拷贝数为105,其HBV-LP浓度为92.76,健康群众的HBV-LP浓度为0.22。数据差异具有统计学意义(P<0.05)。对照组(健康群众)的HBV-LP阳性率(0.00%)与研究组(乙肝患者)阳性率(72.73%、82.76%、96.36%)比较,存在着明显的差异,数据差异具有统计学意义(P<0.05)。乙肝患者HBV-DNA、HBV-Pre SI与HBeAg的阳性率明显低于HBV-LP,数据差异具有统计学意义(P<0.05)。结论血清乙肝病毒大蛋白在HBeAg阴性与低水平HBV-DNA乙肝患者中的检测意义显著,可对患者的乙肝活性与肝脏的受损状况以及病情的发展情况等进行有效的反应,对其病情的诊断以及病情变化情况的掌握有着明显的意义,具有在临床上广泛推广的价值。
Objective To analyze the significance of serum hepatitis B virus large protein in HBeAg-negative and low-level HBV-DNA hepatitis B patients. Methods Convenient selection of 150 cases of hepatitis B patients admitted from May to December 2015 in this hospital and 150 healthy people participated in the physical examination as the object of this experiment. According to the differences of their disease characteristics, the participants were divided into two groups Different groups, hepatitis B patients for the study group, healthy people as the control group, the average of each group members are 150 cases, both groups were tested by enzyme-linked immunosorbent assay, the differences in the detection of indicators were observed and analyse. The results showed that there was a positive correlation between the concentration of HBV-LP and HBV-DNA copy number. The concentration of HBV-LP increased with the increase of its copy number. The HBV-DNA copy number was less than 103 and the HBV-LP concentration was 9.82 , The DNA copy number was 103-105, the HBV-LP concentration was 15.43 and the DNA copy number was 105, the HBV-LP concentration was 92.76, and the healthy people’s HBV-LP concentration was 0.22. Data differences were statistically significant (P <0.05). The positive rate of HBV-LP (0.00%) in the control group (healthy people) was significantly higher than that in the study group (72.73%, 82.76%, 96.36%), and the difference was statistically significant P <0.05). The positive rates of HBV-DNA, HBV-Pre SI and HBeAg in HBV patients were significantly lower than those in HBV-LP patients (P <0.05). Conclusion Serum hepatitis B virus large protein in HBeAg-negative and low-level HBV-DNA in patients with hepatitis B detection of significant significance in patients with hepatitis B activity and liver damage as well as the development of the disease and other effective response to the disease Diagnosis and changes in the condition of the grasp has obvious significance, with a wide range of clinical value.