论文部分内容阅读
目的:考察注射用拉氧头孢钠与甲硝唑注射液配伍的稳定性。方法:采用高效液相色谱法测定拉氧头孢钠与甲硝唑配伍后配伍液中各自含量,并通过精密度试验和配伍稳定性试验,观察0,1,2,4,6和8 h时配伍液外观性状和pH值变化情况。结果:在室温条件下,拉氧头孢钠与甲硝唑的配伍液在各时间段的外观、含量及pH值均未发生明显变化。结论:注射用拉氧头孢钠与甲硝唑注射液配伍的稳定性较好,联合使用的有效性和安全性均能得到保证。
Objective: To investigate the stability of compatibility of dexamethasone injection and metronidazole injection. Methods: The content of dexamethasone sodium and metronidazole in compatibility liquid was determined by high performance liquid chromatography (HPLC). Through the precision test and compatibility stability test, Compatibility characteristics and appearance of the pH changes. Results: At room temperature, there was no obvious change in the appearance, content and pH value of the mixed solution of cefotaxime sodium and metronidazole in each time period. Conclusion: The stability of compatibility between injection of dexamethasone injection and metronidazole injection is good, and the validity and safety of combination can be guaranteed.