论文部分内容阅读
目的:评价甲泼尼龙琥珀酸钠与硫酸镁持续静脉泵注对重症支气管哮喘患者的临床疗效及其对肺功能的影响。方法:选取2016年1月—2017年1月期间诊治的重症支气管哮喘患者85例资料,采用数字随机法将其分为对照组(42例)和治疗组(43例);对照组患者给予甲泼尼龙琥珀酸钠治疗,治疗组患者在对照组治疗基础上加用硫酸镁注射液持续静脉泵注治疗,比较两组患者用药后的肺功能指标及总有效率的变化情况。结果:治疗前两组患者的肺功能指标如呼气峰流速(PEF)、用力肺活量(FVC)与1 s用力呼气容积(FEV1)测得值经比较其差异无统计学意义(P>0.05),治疗后两组患者的PEF、FVC和FEV1测得值均高于治疗前(P<0.05);治疗组患者治疗后的PEF、FVC和FEV1测得值均高于对照组(P<0.05),总有效率为93.02%高于对照组为78.57%(P<0.05)。结论:采用甲泼尼龙琥珀酸钠与硫酸镁持续静脉泵注治疗重症支气管哮喘患者,可有效地改善患者的肺功能指标,缓解了其症状,疗效优于单用甲泼尼龙琥珀酸钠。
Objective: To evaluate the clinical efficacy of methylprednisolone sodium succinate and magnesium sulfate in patients with severe bronchial asthma by continuous intravenous infusion and its effect on pulmonary function. Methods: A total of 85 patients with severe bronchial asthma who were diagnosed and treated between January 2016 and January 2017 were selected and divided into control group (n = 42) and treatment group (n = 43) by digital random method. Patients in control group Prednisolone sodium succinate treatment, the treatment group patients in the control group plus magnesium sulfate injection on the basis of continuous intravenous infusion therapy, the two groups of patients after treatment of lung function index and total effective rate changes. Results: There was no significant difference in the lung function parameters such as peak expiratory flow (PEF), forced vital capacity (FVC) and forced expiratory volume (FEV1) between the two groups before treatment (P> 0.05 ). The measured values of PEF, FVC and FEV1 in both groups after treatment were higher than those before treatment (P <0.05). The measured values of PEF, FVC and FEV1 in the treatment group were significantly higher than those in the control group ), The total effective rate was 93.02% higher than the control group was 78.57% (P <0.05). CONCLUSION: Continuous intravenous injection of methylprednisolone sodium succinate and magnesium sulfate for patients with severe bronchial asthma can effectively improve the patients’ pulmonary function indexes and relieve their symptoms, and the curative effect is better than that of methylprednisolone sodium succinate alone.