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目的:分析噻托溴铵与孟鲁司特钠联用治疗慢性阻塞性肺疾病患者的疗效。方法:选取2015年6月—2016年6月间收治的慢性阻塞性肺疾病患者120例;将其分为孟鲁司特钠组、噻托溴铵组和联用组,每组40例;分别给予单用孟鲁司特钠,单用噻托溴铵,和孟鲁司特钠与噻托溴铵联用治疗;比较3组患者治疗后的总有效率、治疗前后肺功能各指标(FEV1、PEF和FEV1/FVC百分率)、呼吸困难症状评分值及6 min步行试验(6 MWT)评分值变化情况以及治疗期间药物不良反应的发生情况。结果:联用组患者治疗后的总有效率明显高于孟鲁司特钠组和噻托溴铵组(P<0.05);治疗后FEV1、PEF、FEV1/FVC百分率均高于孟鲁司特钠组和噻托溴铵组(P<0.05);治疗后呼吸困难症状评分值及6 MWT评分值均低于孟鲁司特钠组和噻托溴铵组(P<0.05);3组患者治疗期间服药所致不良反应的发生率经比较其差异无统计学意义(P>0.05)。结论:采用噻托溴铵与孟鲁司特钠联用治疗方案,能够有效改善慢性阻塞性肺疾病患者呼吸困难症状和肺功能各指标,临床疗效较显著,安全性较高。
Objective: To analyze the efficacy of tiotropium combined with montelukast sodium in the treatment of patients with chronic obstructive pulmonary disease. Methods: 120 patients with chronic obstructive pulmonary disease who were admitted between June 2015 and June 2016 were selected and divided into montelukast sodium group, tiotropium group and combination group, 40 cases in each group. Were given montelukast sodium, tiotropium alone, montelukast sodium and tiotropium combined treatment; comparison of the total effective rate after treatment in three groups, before and after treatment of lung function indicators FEV1, PEF and FEV1 / FVC percentage), dyspneic symptom scores and 6-MWT scores, and the incidence of adverse drug reactions during treatment. Results: The total effective rate in the combined group was significantly higher than that in the montelukast sodium group and tiotropium group (P <0.05). The percentages of FEV1, PEF and FEV1 / FVC after treatment were higher than those in the montelukast Sodium group and tiotropium group (P <0.05). After treatment, scores of dyspnea symptom score and 6 MWT score were lower than those of montelukast sodium group and tiotropium group (P <0.05) The incidence of adverse reactions caused by taking medication during the treatment had no significant difference (P> 0.05). Conclusion: The combination therapy of tiotropium and montelukast sodium can effectively improve the symptoms of dyspnea and the indexes of lung function in patients with chronic obstructive pulmonary disease. The clinical effect is more obvious and the safety is higher.