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目的探讨腹腔镜手术联合促性腺激素释放激素激动剂(GnRH-a)治疗子宫内膜异位症的临床疗效及其对患者生活质量的影响。方法选取禹州市妇幼保健院2012年1月—2015年10月收治的子宫内膜异位症患者108例,根据不同治疗方案分为对照组与观察组,各54例。对照组患者行腹腔镜手术治疗,观察组患者在对照组基础上联合GnRH-a治疗。比较两组患者临床疗效、1年复发率、治疗前后生活质量评分、并发症及不良反应发生情况。结果两组患者治疗总有效率比较,差异无统计学意义(P>0.05)。观察组复发率低于对照组(P<0.05)。治疗前两组患者躯体功能、心理功能、社会功能、物质生活状态评分比较,差异无统计学意义(P>0.05);治疗后观察组患者躯体功能、心理功能、社会功能、物质生活状态评分高于对照组(P<0.05)。两组患者均未出现严重并发症及不良反应。结论腹腔镜手术联合GnRH-a治疗子宫内膜异位症的临床疗效确切,可改善患者生活治量,降低术后复发率。
Objective To investigate the clinical efficacy of laparoscopic surgery combined with gonadotropin-releasing hormone agonist (GnRH-a) in the treatment of endometriosis and its impact on quality of life of patients. Methods 108 cases of endometriosis admitted in Yuzhou Maternal and Child Health Hospital from January 2012 to October 2015 were divided into control group and observation group with 54 cases in each group. Patients in the control group underwent laparoscopic surgery. Patients in the observation group were treated with GnRH-a on the basis of the control group. The clinical efficacy, recurrence rate at 1 year, quality of life before and after treatment, complication and adverse reactions were compared between the two groups. Results The total effective rate of the two groups of patients was no significant difference (P> 0.05). The recurrence rate of the observation group was lower than that of the control group (P <0.05). There was no significant difference in body function, mental function, social function and physical status score between the two groups before treatment (P> 0.05). After treatment, the body function, mental function, social function and physical living status of the observation group were high In the control group (P <0.05). Two groups of patients did not appear serious complications and adverse reactions. Conclusion Laparoscopic surgery combined with GnRH-a treatment of endometriosis clinical curative effect, can improve patient life rule, reduce postoperative recurrence rate.