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目的:观测急进高原低氧环境,降钙素基因相关肽等6种血管活性多肽含量的动态变化,探索人体在急性缺氧时的生理调节过程。方法:用放射免疫法测定41名健康青年男性志愿者在海拔1 100 m世居地,进入海拔2 260 m 3月、海拔3 780 m 1 d、5 d和15 d动脉血浆降钙素基因相关肽(CGRP),内皮素(ET)等物质的含量。结果:动脉血浆舒血管物质CGRP、CNP、-βEP和NT浓度明显增加。而缩血管物质ET的含量在进入海拔3 780 m 5 d时显著下降(与海拔1 100 m、2 260 m和3 780 m 1 d相比差别显著,P<0.01),NPY含量不同海拔间无显著性差异。结论:动脉血中血管活性物质含量变化为血管舒张因子的含量显著增加,血管收缩因子含量明显下降,表明人体在急性缺氧时,血管扩张在肺循环对低氧的生理性调节中占主导地位。
OBJECTIVE: To observe the dynamic changes of 6 vasoactive peptides in acute hypoxia environment, calcitonin gene-related peptide, and to explore the physiological regulation of human during acute hypoxia. Methods: Forty-one healthy young male volunteers were detected by radioimmunoassay at an altitude of 1 100 m, with an altitude of 2260 m 3, an elevation of 3 780 m 1 d, and calcitonin gene-related Peptide (CGRP), endothelin (ET) and other substances. Results: The concentrations of CGRP, CNP, -EP and NT in arterial plasma vasodilators increased significantly. The contents of vasoconstrictor ET decreased significantly at 3 780 m 5 d (P <0.01) compared with those at 11 100 m, 2260 m and 3780 m 1 d, and the contents of NPY in different elevations Significant difference. CONCLUSION: The content of vasoactive substances in arterial blood changes significantly as the content of vasodilators and the content of vasoconstriction factor decrease obviously, indicating that in the acute hypoxia, vasodilation is predominant in the physiological regulation of hypoxia by pulmonary circulation.