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目的探讨循环内皮细胞（ＣＥＣ）、内皮素（ＥＴ）Ｎ一氧化氮（ＮＯ）在创伤大白兔外周血中的变化规律及意义。方法实验动物分为创伤组、治疗组及对照组；分别观察各组中 ＣＥＣ， ＥＴ及 ＮＯ的变化及伤情。结果①创伤组外周血中ＥＴ，ＮＯ含量早期急剧升高，后期又急剧下降，变化波动极大，其多脏器功能不全综合征（ＭＯＤＳ）的发生率及病死率显著高于其他两组；在血管内皮细胞（ＶＥＣ）损伤的前期或早期，即在ＥＴ，ＮＯ含量升高以前或早期应用细胞保护剂处理的治疗组，外用血中 ＥＴ，ＮＯ含量变化较小，且 ＭＯＤＳ发病率及病死率显著降低。②外周血中ＣＥＣ计数随伤情的加重而增多；外周血中ＥＴ，ＮＯ含量随伤情的加重先升而后降，并随伤情的恢复而恢复。结论①外用血中ＥＴ，ＮＯ含量变化在ＭＯＤＳ的发病机制中及对ＭＯＤＳ的预诊和防治有着重要的意义。②外周血中ＣＥＣ的计数、ＥＴ、ＮＯ含量变化与创伤伤情关系密切，并可作为创伤伤情的评估指标。
Objective To investigate the changes and significance of circulating endothelial cells (CEC) and endothelin (N-nitric oxide) in peripheral blood of traumatic rabbits. Methods The experimental animals were divided into trauma group, treatment group and control group. The changes of CEC, ET, NO and injury in each group were observed. Results ① The content of ET and NO in peripheral blood of trauma group increased sharply in the early stage and sharply decreased in the late stage. The fluctuation of ET and NO in the trauma group was extremely high. The incidence and mortality of MODS in the traumatic group were significantly higher than those in the other two groups. In the early or early stage of vascular endothelial cell (VEC) injury, that is, the ET and NO levels in external blood were little changed before or at the beginning of ET or NO treatment, or the cells treated with cytoprotective agent earlier, and the morbidity and mortality of MODS The rate is significantly lower. ② CEC count in peripheral blood increased with the aggravating of injury; ET and NO content in peripheral blood increased first and then decreased with the increase of injury, and recovered with the recovery of injury. Conclusion ① The changes of ET and NO in blood are of great significance in the pathogenesis of MODS and the diagnosis and treatment of MODS. ② The count of CEC, ET and NO in peripheral blood were closely related to traumatic injury, and could be used as the evaluation index of traumatic injury.