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实验利用猫双侧颈总动脉(bCA)和双侧椎动脉(bVA)中不同数目血管阻断观察了脑缺血对心电图(ECG)的影响。bCA并单侧椎动脉(uVA)或bCA+bVA阻断均引起复杂ECG变化,如Q-T时程从对照值0.21±0.04s分别延长至0.23+0.08s和0.25±0.11 s,心率由179±33次/min分别降至173±27次/min和151±39次/min,与对照值比较P<0.01。结果显示颈动脉窦反射是bCA或bCA±uVA阻断早期出现短暂心律失常的原因;bCA+uVA阻断所致的迟发ECG变化与缺血引起的颅内压(ICP)升高有关;而bCA+bVA阻断引起的窦性心动过缓、室性心律失常等变化是由于脑干缺血所致,与ICP变化无关。结果提示颅内疾病时心动过缓、室性心律失常的出现,可能预示着脑干结构的损害和功能紊乱。
The effects of cerebral ischemia on the electrocardiogram (ECG) were observed using different numbers of vascular occlusions in the bCA and bVA of the cat. BCA and unilateral vertebral artery (uVA) or bCA + bVA block caused complex ECG changes, such as QT duration from the control 0.21 ± 0.04s were extended to 0.23 +0.08 s and 0.25 ± 0.11 s, the heart rate increased from 179 ± 33 Times / min were reduced to 173 ± 27 times / min and 151 ± 39 times / min, compared with the control value P <0.01. The results showed that carotid sinus reflex was the reason of bCA or bCA ± uVA blocking the early transient arrhythmia; the delayed ECG changes induced by bCA + uVA block were related to the increase of intracranial pressure (ICP) induced by ischemia; and BCA + bVA block caused by sinus bradycardia, ventricular arrhythmia and other changes due to ischemia caused by the brainstem, and has nothing to do with ICP changes. The results suggest that intracranial disease bradycardia, ventricular arrhythmia may indicate the damage of brain stem structure and dysfunction.