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目的：评价联合使用地塞米松及非那根降低离子型造影剂的副作用。材料和方法：随机将４００ 例患者分为两组，一组在使用造影剂前１ ～２ 小时静脉注射１０ ｍｇ 地塞米松及肌肉注射非那根５０ ｍ ｇ ，另一组不给预防药。结果：预防用药组造影剂总的副作用发生率为１１ ％ ，对照组为１９．５ ％ 。对照组打喷嚏、恶心／ 呕吐、口干／ 咽喉搔痒感及皮肤潮红／ 荨麻疹的发生率分别为８．５ ％ ，１２．５ ％ ，１３．５ ％ 和１２ ％ ，而预防用药组分别是３ ％ ，４ ％ ，７．５ ％ 和３．５ ％ 。结论：联合使用地塞米松及非那根能明显降低患者对离子型造影剂的副作用发生率。
OBJECTIVE: To evaluate the side effects of dexamethasone and fentanyl in reducing ionic contrast agents. MATERIALS AND METHODS: Four hundred patients were randomized into two groups. One group received intravenous injection of 10 mg dexamethasone 1 to 2 hours prior to administration of contrast medium and intramuscular injection of 50 mg fenofibrate, while the other group received no prophylaxis. RESULTS: The overall incidence of adverse events in the prophylaxis group was 11% and in the control group 19.5%. In the control group, the incidences of sneezing, nausea / vomiting, dry mouth / pruritus and skin flushing / urticaria were 8.5%, 12.5%, 13.5% and 12%, respectively, while the prophylaxis groups were 3%, 4%, 7.5% and 3.5%. Conclusion: Combination of dexamethasone and phenazon significantly reduces the incidence of side effects in patients with ionic contrast agents.