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目的 研究并总结前列地尔脂微球载体制剂凯时注射液(Lipo PGE1 ) 对各种常见原因肾病变致早期慢性肾功能损害的疗效。方法 收集20例各种肾病致早期慢性肾功能损害患者作为观察组, 在原有治疗的基础上加凯时10μg; 对照组20例, 在原有治疗的基础上加用黄芪注射液50 ml治疗; 两组药物均溶于生理盐水中静脉滴注, 1次/日, 两周为一个疗程。结果 两组临床症状(水肿、尿量) 与肾功能(BUN、Cr) 均显著改善, 与治疗前相比肾功能改善(BUN、Cr下降) 明显, 有显著性差异(P<0 01)。而凯时组与黄芪组相比, 临床症状肾功能改善, 无显著性差异(P>0 05)。结论 凯时治疗各种肾病致早期慢性肾功能损害, 疗效满意, 副作用少在临床中使用效果显著。
Objective To study and summarize the efficacy of Lipo PGE1, a precursor of liposome-loaded microspheres, in the treatment of early-stage chronic renal impairment caused by various common causes of nephropathy. Methods 20 patients with early renal damage caused by various kinds of nephropathy were collected as the observation group. When the treatment group was added Kai 10μg, the control group 20 cases were treated with Radix astragali injection 50 ml on the basis of the original treatment. Group drugs were dissolved in saline intravenously, 1 time / day, two weeks for a course of treatment. Results The clinical symptoms (edema and urine volume) and renal function (BUN and Cr) in both groups were significantly improved. Compared with the pretreatment, the improvement of renal function (BUN and Cr decreased) was significant (P <0.01). Compared with the Astragalus group, the clinical symptoms and renal function of Kai-shi group were improved, there was no significant difference (P> 0.05). Conclusions Kay hours treatment of various renal diseases caused by early chronic renal impairment, with satisfactory results, less side effects in the clinical use of significant effect.