牙周炎是一种病因复杂的微生物感染性疾病,其患病率高于龋病[1],主要以G-菌和厌氧菌感染为主。致病菌一方面通过多种途径分泌大量的内毒素脂多糖(LPS)、酸性和碱性磷酸酶等毒性因子造成牙周组织破坏,另一方面激发宿主的炎性免疫反应,成为某些全身性疾病发生的危险因素[2]。本世纪以来,药物剂型和试剂研究进入药物释放系统(DDS)时代,新型 Periodontitis is a complex cause of microbial infections, its prevalence higher than caries [1], mainly G-bacteria and anaerobic infections. Pathogens on the one hand through a variety of ways to secrete a large number of endotoxin lipopolysaccharide (LPS), acid and alkaline phosphatase and other toxic factors cause periodontal tissue damage, on the other hand stimulate the host inflammatory immune response, as some of the body Risk factors for the occurrence of sexually transmitted diseases [2]. Since the turn of the century, pharmaceutical dosage forms and reagents have entered the era of drug delivery systems (DDS)