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近年来,AFP 在临床上起着重要作用。但也见慢性肝炎或肝硬化患者 AFP 阳性,与 AFP值较低的肝细胞癌较难鉴别。1984年 Liebman用单克隆抗体放射免疫法测定异常凝血酶元PIVKA-Ⅱ,在肝细胞癌病例中,检出率为91％,而且67％的病人出现300ng/ml 以上的高值。作者以各种肝病及其他脏器癌症为对象,用抗 PIVKA-Ⅱ单克隆抗体 EIA 小盒,测定血浆 PIVKA-Ⅱ,研究其临床意义。测定肝细胞癌及胆汁淤积症的血浆维生素 K,探讨与PIVKA-Ⅱ的相关性。
In recent years, AFP plays an important role in clinical practice. But also see AFP positive in patients with chronic hepatitis or cirrhosis, and the lower the AFP value of HCC more difficult to identify. 1984 Liebman monoclonal antibody radioimmunoassay determination of abnormal prothrombin PIVKA-Ⅱ, in hepatocellular carcinoma cases, the detection rate was 91%, and 67% of patients showed a high value of 300ng / ml or more. The author of a variety of liver disease and other organ cancer as the object, with anti-PIVKA-Ⅱ monoclonal antibody EIA box, measured plasma PIVKA-Ⅱ, to study its clinical significance. Determination of plasma vitamin K in hepatocellular carcinoma and cholestasis, and to explore the correlation with PIVKA-Ⅱ.