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用放射免疫法同时测定１１４例肝病患者血清Ⅲ型前胶原（ＰＣ－Ⅲ）、Ⅳ型胶原片段（Ⅳ－Ｃ）、层粘连蛋白（ＬＮ）和透明质酸（ＨＡ）水平。结果表明，慢性肝病组ＰＣ－Ⅲ水平高于正常人（Ｐ＜０．０５），但在慢性肝炎和肝硬化之间无显著性差异（Ｐ＞０．０５）。重度慢性肝炎及肝硬化Ⅳ－Ｃ水平升高较ＰＣ－Ⅲ和ＬＮ显著；中度慢性肝炎时ＬＮ水平即显著升高；急性肝炎时ＨＡ显著升高后，从中度慢性肝炎始ＨＡ水平显著升高（Ｐ＞０．００１），肝硬化时最高。表明血清ＨＡ水平反映肝损伤，病变活动及纤维化程度的敏感性优于ＰＣ－Ⅲ、Ⅳ－Ｃ和ＬＮ，是良好的血清学指标。
Serum levels of type III procollagen (PC-Ⅲ), type Ⅳ collagen (Ⅳ-C), laminin (LN) and hyaluronic acid (HA) were determined by radioimmunoassay in 114 patients with liver disease. The results showed that the level of PC-Ⅲ in chronic liver disease group was higher than that in normal people (P <0.05), but there was no significant difference between chronic hepatitis and cirrhosis (P> 0.05). Severe chronic hepatitis and liver cirrhosis Ⅳ-C levels were significantly higher than those of PC-Ⅲ and LN; LN levels were significantly increased in patients with moderate chronic hepatitis; HA was significantly increased in acute hepatitis, the level of HA was significantly increased from moderate chronic hepatitis High (P> 0.001), cirrhosis highest. The results showed that the sensitivity of serum HA to liver damage, lesion activity and fibrosis was better than that of PC-Ⅲ, Ⅳ-C and LN, which was a good serological index.