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目的临床观察痰热清注射液辅助治疗重型手足口病的疗效。方法选择住院经确诊为重型手足口病患儿160例随机分为治疗组、对照组,每组各80例。对照组按2010年卫生部颁发的手足口病治疗方案常规治疗:甘露醇降颅压,人血免疫球蛋白调节免疫,甲泼尼龙抗炎症反应及减轻脑水肿,利巴韦林抗病毒,补充维生素及其它综合对症支持治疗,伴细菌感染者给抗生素等应用。治疗组在对照组的基础上加用痰热清注射液静脉滴注。结果治疗组患儿临床症状和体征消退时间、住院时间方面均短于对照组,差异具有统计学意义(P<0.05)。两组临床疗效比较,治疗组总有效率93.75%,对照组总有效率82.5%,差异有统计学意义(χ2=4.82,P<0.05)。结论痰热清注射液辅助治疗重型手足口病疗效优于常规治疗组。
Objective To observe the effect of Tanreqing injection in the treatment of severe hand-foot-mouth disease. Methods 160 hospitalized children with HFMD were randomly divided into treatment group and control group with 80 cases in each group. Control group according to the 2010 Ministry of Health hand, foot and mouth disease treatment routine treatment: mannitol intracranial pressure, immune regulation of human immunoglobulin, methylprednisolone anti-inflammatory response and reduce cerebral edema, ribavirin antiviral, add Vitamins and other integrated symptomatic supportive treatment, with bacterial infections to antibiotics and other applications. Treatment group in the control group based on the addition of phlegm heat injection intravenous drip. Results The clinical symptoms and signs of patients in the treatment group were both shorter than those in the control group in the regression time and hospitalization duration, with significant difference (P <0.05). The total effective rate was 93.75% in the treatment group and 82.5% in the control group, the difference was statistically significant (χ2 = 4.82, P <0.05). Conclusion Tanreqing injection adjuvant treatment of severe hand-foot-mouth disease is better than the conventional treatment group.