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目的探讨直肠指检(DRE)、导尿术(UC)等相关因素对前列腺特异性抗原(PSA)检测结果的影响。方法将60例健康者分为DRE组和UC组,每组30例。采用对比分析的方法分别观察DRE和UC前后血清PAS检测值的变化情况。结果DRE前PSA(FPSA)和后PSA(TPSA)平均值为(1.05±0.10、2.82±0.97)ng/ml,DRE后第1、3、7天分别为(1.07±0.15、3.50±1.95)、(1.03±0.06、2.97±1.66)、(1.02±0.07、3.25±1.71)ng/ml;DRE组FPSA无显著升高,TPSA有所升高,于24h达最大值,其次为第7、3天。经统计学分析,DRE前后各组间PSA值均无显著性差异(P>0.05)。UC的FPSA和TPSA平均值为(1.00±0.02、2.01±0.50)ng/ml,UC后第1、3、7天分别为(1.15±0.82、2.37±1.96)、(1.02±0.07、2.16±0.52)、(1.02±0.09、2.09±0.60)ng/ml;UC组FPSA术后24h有所升高,TPSA术后24h达最高值,之后逐渐降低,经统计学分析,UC前后各组间PSA值均无显著性差异(P>0.05)。结论正常血清PSA检测结果不受DRE和UC等因素的影响。
Objective To investigate the effect of related factors such as digital rectal examination (DRE) and catheterization (UC) on the detection of prostate specific antigen (PSA). Methods Sixty healthy subjects were divided into DRE group and UC group, 30 cases in each group. The changes of serum PAS values before and after DRE and UC were observed by comparative analysis. Results The mean values of FPSA and TPSA before and after DRE were (1.05 ± 0.10,2.82 ± 0.97) ng / ml, (1.07 ± 0.15 and 3.50 ± 1.95) days after DRE, (1.03 ± 0.06, 2.97 ± 1.66) and (1.02 ± 0.07, 3.25 ± 1.71) ng / ml, respectively. There was no significant increase in FPSA and TPSA in DRE group, reaching the maximum at 24h, followed by days 7 and 3 . After statistical analysis, there was no significant difference in PSA between before and after DRE (P> 0.05). The average values of FPSA and TPSA in UC patients were (1.00 ± 0.02, 2.01 ± 0.50) ng / ml, and were 1.15 ± 0.82, 2.37 ± 1.96, 1.02 ± 0.07, 2.16 ± 0.52 ), (1.02 ± 0.09,2.09 ± 0.60) ng / ml respectively. The level of FPSA in UC group increased at 24h and reached the peak at 24h after TPSA, and then decreased gradually. After statistical analysis, No significant difference (P> 0.05). Conclusion The results of normal serum PSA test are not affected by factors such as DRE and UC.