[第五报:长期呼入与呼吸器官病变的推移]用重油燃烧生成物对大白鼠进行了二系列长期(终生)吸入实验,研究了呼吸器官的形态学的病变。发现引起有喉头炎、支气管炎、细支气管炎、弥漫性肺纤维症、肺胞间质炎,并形成肺和肺淋巴炭粉症。同已往报告过的32日和105日暴露的二实验系列所见对比,如追踪呼吸器官病变的进展,则呼吸道粘膜病变是根据发生部位与病变强度和进行速度而异,但一般来说,从伴有分泌亢进初期卡他性炎症起,直到经过上皮细胞的 [Fifth newspaper: long-term inhalation and respiratory organ changes] with heavy oil combustion products in rats conducted a series of two long-term (lifelong) inhalation experiments to study the morphological changes of respiratory organs. Found to cause laryngitis, bronchitis, bronchiolitis, diffuse pulmonary fibrosis, interstitial pneumonitis, and the formation of lung and pulmonary lymphoma carbon powder disease. In contrast to previous reports of two experimental series of exposures on days 32 and 105 that track the progression of respiratory disease, mucosal lesions of the respiratory tract vary depending on the site of the lesion and the intensity and rate of the lesion, but in general, Activated hyperthyroidism with catarrhal inflammation, until after the epithelial cells