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目的:讨论慢性丙型肝炎患者血清自身抗体存在情况及临床意义。方法:应用美国英明道斑点金标法检测67例慢性丙型肝炎患者及30例健康正常人血清中的自身抗体抗核抗体(ANA),并比较其与HCV RNA的关系。结果:67例慢性丙型肝炎患者中有25例自身抗体ANA阳性,总阳性率37.3%,明显高于健康对照组的3.3%,差异有统计学意义(2χ=8.37,P<0.05)。HCVRNA阳性组的自身抗体检出率(45.69%)与HCVRNA阴性组自身抗体检出率(19.19%)相比较,差异有统计学意义(χ2=4.16,P<0.05)。结论:慢性丙型肝炎患者中普通存在自身免疫现象,自身抗体的检出率与HCVRNA阳性明显相关,检测自身抗体对慢性丙型肝炎患者的诊断与治疗有重要参考价值。
Objective: To discuss the status of serum autoantibodies in patients with chronic hepatitis C and its clinical significance. Methods: The anti-nuclear antibody (ANA) in sera of 67 patients with chronic hepatitis C and 30 normal controls were detected by immunocytochemical staining method in Yingming Road of USA. Results: Among 67 chronic hepatitis C patients, 25 were autoantibodies positive for ANA, the total positive rate was 37.3%, which was significantly higher than 3.3% of healthy controls (2χ = 8.37, P <0.05). The detection rate of autoantibodies in HCVRNA positive group (45.69%) and HCVRNA negative group (19.19%) were significantly different (χ2 = 4.16, P <0.05). Conclusion: There is a common autoimmune phenomenon in patients with chronic hepatitis C, the detection rate of autoantibodies is significantly correlated with the positive of HCVRNA, and the detection of autoantibodies is of important reference value in the diagnosis and treatment of patients with chronic hepatitis C.