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目的探讨人巨细胞病毒(human cytomegalovirus,HCMV)感染对婴幼儿肝肾功能的影响。方法回顾性分析143例HCMV感染的婴幼儿的肝肾功能指标,并与对照组比较,实验数据采用SPSS15.0统计软件处理并进行分析。结果观察组肝肾功能指标丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、r-谷氨酰转移酶(GGT)、血肌酐(Scr)均高于对照组,差异均有统计学意义(P值=0.000～0.05)。肝功能异常发生率为76.22%,肾功能异常发生率为6.99%。结论婴幼儿HCMV感染时多数存在肝功能损害,部分存在肾功能损害,诊治时应注意监测和保护肝肾功能。
Objective To investigate the effect of human cytomegalovirus (HCMV) infection on liver and kidney function in infants and young children. Methods Retrospective analysis of 143 cases of HCMV infection in infants and young children liver and kidney function indicators, and compared with the control group, the experimental data using SPSS15.0 statistical software processing and analysis. Results The liver and kidney function indexes of ALT, AST, GGT and Scr in observation group were higher than those in control group, The differences were statistically significant (P = 0.000 ~ 0.05). The incidence of abnormal liver function was 76.22%, the incidence of renal dysfunction was 6.99%. Conclusions Most cases of HCMV infection in infants and young children have liver dysfunction and some of them have impaired renal function. At diagnosis and treatment, attention should be paid to monitor and protect liver and kidney functions.