随着社会的发展 ,迫切需要研制可供男性选用、安全高效、可复性和可接受性均好的避孕药。男性激素类避孕是当今最有前途的方法之一 ,其基本原理是通过外源性激素来抑制垂体促性腺激素和睾丸内睾酮的合成与分泌 ,进而抑制精子发生 ;同时给予的外源雄激素维持男性性征和性功能。研究中的男性激素避孕方法 ,包括单用雄激素、雄激素与孕激素合用、GnRH类似物与雄激素合用、激素相关的免疫途径等 ,寻求更长效、使用更方便、副作用小的雄激素制剂也是当今研究的重点之一 With the development of society, there is an urgent need to develop contraceptives that are safe for men, safe and efficient, reproducible and acceptable. Male hormonal contraception is one of the most promising methods today. Its basic principle is to inhibit the synthesis and secretion of pituitary gonadotropin and testosterone in testis by exogenous hormones, thereby inhibiting spermatogenesis; at the same time, exogenous androgen administration is maintained Male sexual characteristics and sexual function. The male hormonal contraceptive methods under study include androgens, combination of androgens with progestins, use of GnRH analogs with androgens, and hormone-related immunological routes to find more and more effective, less toxic and less potent Formulation is also one of the focuses of today’s research