Williams指出糖尿病患者与无糖尿病患者牙周病特征是不相同的,他认为糖尿病患者的牙周病应叫作“糖尿病性牙周溃坏”(diabetic peviodontoclasia)。Glickman用实验对照方法最早研究了这一问题,他提出“临床观察到的糖尿病患者的口腔病变是否实际上就是前者引起的后果?”这个问题引起了对糖尿病患者牙周病病原学一系列的研究。 Williams pointed out that diabetic patients with periodontal disease characteristics are not the same with non-diabetic patients, he thinks periodontitis in diabetic patients should be called “diabetic periodontal collapse” (diabeticpeviodontoclasia). Glickman's earliest study of this problem with an experimental control method, he proposed “whether clinically observed oral disease in diabetic patients is actually the former consequences?” This issue has led to a series of studies on periodontal pathogens in diabetic patients .