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在遗传上有缺陷的动物，具有能够近似地模拟人类某些疾病的特性。因此，常被作为研究人类疾病的动物模型。其中Ｔ细胞缺陷的裸小鼠在国内外最常用，特别是在肿瘤研究中应用更为有效。为推广扩大该实验动物在我省的应用，我们本着投资少，见效快的方针，建立了小规模的饲养繁殖体系。保种及生产繁殖的裸小鼠饲养在隔离器中，实验用裸小鼠饲养在层流架中带滤帽的笼盒内。着重抓好环境控制，消毒灭菌，营养和人员素质等关键环节，取得了裸小鼠在我单位的首次繁育成功，并应用于食管癌移植瘤模型的建立等研究。
Genetically defective animals have characteristics that can simulate certain diseases in humans. Therefore, it is often used as an animal model to study human diseases. One of the most common T cell deficient mice at home and abroad, especially in cancer research more effective. In order to promote and expand the application of this laboratory animal in our province, we have established a small-scale breeding system based on the principle of less investment and quick results. Breeding and breeding The nude mice were housed in an isolator and nude mice were housed in cage with filter cap in a laminar flow frame. Focus on key aspects of environmental control, disinfection and sterilization, nutrition and quality of personnel and achieved nude mice in my unit’s first successful breeding, and applied to the establishment of esophageal cancer xenograft model.