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目的：为溃疡病的发病机理及临床防治提供形态学根据。方法：采用Ｋａｒｎｏｖｓｋｙ－Ｒｏｏｔｓ法，观察了１０例溃疡病人及４例正常人胃壁胆碱能神经纤维分布特点，并做统计学处理，结果：胃壁各层均有红棕色的乙酰胆碱酯酶（ＡＣｈＥ）阳性纤维，但粘膜上皮和固有层上部未见ＡＣｈＥ阳性纤维。检测胃壁ＡＣｈＥ阳性纤维分布密度，病人（２．６８±０．１０）高于正常人（１．１４±０．０１），Ｐ＜０．０１。结论：溃疡病发病与胆碱能神经密切相关。
Objective: To provide the morphological basis for the pathogenesis and clinical prevention and treatment of ulcer disease. Methods: The Karnovsky-Roots method was used to observe the distribution of gastric cholinergic nerve fibers in 10 patients with ulcer and 4 normal persons. Statistical analysis was performed. The results showed that there were red-brown acetylcholinesterase (AChE) Positive fibers, but there was no AChE-positive fibers in the mucosal epithelium and superior lamina propria. The distribution of AChE-positive fibers in gastric wall was detected, which was significantly higher in patients (2.68 ± 0.10) than in normal controls (1.14 ± 0.01), P <0.01. Conclusion: The incidence of ulcer disease is closely related to cholinergic nerve.