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目的探讨口腔病灶的祛除对男性生育能力的改善情况并从性激素、微量元素两方面探讨其机理。方法选取符合研究条件的男性不育症合并口腔病灶患者80例,随机分为口腔治疗组和中成药治疗组,并进行统计学分析。结果口腔治疗组总有效率为67.5%,中成药治疗组总有效率为45%,两者比较,P<0.05,差异有统计学意义。口腔治疗组治疗后精子密度、活率、A+B级精子、畸形率都比治疗前明显改善,P<0.05,差异有统计学意义;中成药治疗组精子密度、A+B级精子较治疗前有改善,P<0.05,差异有统计学意义,两组治疗前后血清微量元素Zn含量的比较,P<0.05,差异有统计学意义。结论口腔治疗组疗效及精子参数改善优于中成药治疗组,提示口腔病灶的祛除可以改善精子质量,从而有助于提高男性生育能力;口腔病灶对男性不育症的影响可能不是因为性激素的改变,而是由于微量元素Zn的含量下降所致。
Objective To investigate the improvement of male fertility in patients with oral lesions and to explore its mechanism from the aspects of sex hormones and trace elements. Methods A total of 80 male patients with male infertility complicated with oral lesion who met the research conditions were randomly divided into two groups: oral treatment group and Chinese patent medicine treatment group, and statistical analysis was made. Results The total effective rate of oral treatment group was 67.5%, the total effective rate of Chinese medicine group was 45%, both compared, P <0.05, the difference was statistically significant. Sperm density, live rate, A + B grade sperm and deformity rate in oral treatment group were significantly improved than before treatment, P <0.05, the difference was statistically significant; sperm density in treatment group, A + B grade sperm treatment Before improvement, P <0.05, the difference was statistically significant, the two groups before and after treatment of serum trace element Zn content, P <0.05, the difference was statistically significant. Conclusion The improvement of sperm parameters and efficacy of oral treatment group is better than that of traditional Chinese medicine treatment group, suggesting that the removal of oral lesions can improve sperm quality, which can help improve male fertility; oral lesions of male infertility may not be due to changes in sex hormones , But due to the decline of trace element Zn content.