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目的分析肺炎支原体肺炎(MPP)患儿的血清甘露糖结合凝集素(MBL)和唾液酸水平的变化,探讨其在MPP发病机制中的作用。方法选取MPP患儿95例为MPP组,同期参加体检的儿童60例为对照组,两组性别、年龄比较均无统计学差异(均P>0.05)。两组均抽取外周血2ml,用ELISA法检测血清MBL水平,神经氨酸苷酶法检测血清唾液酸水平,分析比较两组MBL和唾液酸水平,探讨两者与MPP的关系。结果 MPP组急性期和恢复期血清MBL水平均显著高于对照组(均P<0.05);MPP组急性期唾液酸水平显著高于对照组(P<0.05),恢复期与对照组比较无统计学差异(P>0.05)。MPP组急性期与恢复期MBL、唾液酸水平比较均无统计学差异(均P>0.05)。结论 MPP患儿血清MBL和唾液酸水平明显增高,可能与机体炎症反应有关。
Objective To analyze the changes of serum mannose binding lectin (MBL) and sialic acid levels in children with Mycoplasma pneumoniae pneumonia (MPP) and explore their roles in the pathogenesis of MPP. Methods Ninety-five children with MPP were selected as MPP group and 60 children participated in the same period as control group. There was no significant difference in gender and age between the two groups (all P> 0.05). Serum MBL levels were measured by ELISA, serum sialic acid levels were measured by neuraminidase method, MBL and sialic acid levels were compared between the two groups to explore the relationship between the two and MPP. Results The level of serum MBL in acute and convalescent MPP group was significantly higher than that in control group (all P <0.05). The sialic acid level in acute phase of MPP group was significantly higher than that in control group (P <0.05) Learning difference (P> 0.05). MPL group acute and convalescent MBL, sialic acid levels were no significant difference (all P> 0.05). Conclusion Serum levels of MBL and sialic acid in MPP children were significantly higher than those in the control group, which may be related to the inflammatory reaction.