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目的合成更强抗癌活性的有机锗化合物,研究分子结构和抗癌活性之间的关系。方法首先合成了4种含蒽醌酰胺和萘酯基团的新型有机锗化合物,用IR,1HNMR和元素分析研究它们的结构。用MTT方法研究化合物对人白血病癌细胞(K562)的抑制作用。结果4种化合物对K562的IC50分别为11.2,16.3,4.8,9.3μmol/L。而参照物2-氨基蒽醌和1-萘酚的IC50分别为771和282μmol/L,Ge-132对体外培养细胞几乎没有抑制作用。结论对Ge-132进行结构修饰,合成的新型有机锗化合物具有抑制体外培养癌细胞增殖的作用。
Aim To synthesize organic germanium compounds with stronger antitumor activity and to study the relationship between molecular structure and anticancer activity. Methods Four novel organic germanium compounds with anthraquinone amide and naphthalene ester groups were synthesized and their structures were studied by IR, 1HNMR and elemental analysis. The inhibitory effect of the compounds on human leukemia cancer cells (K562) was studied by MTT assay. Results The IC50 of the four compounds against K562 were 11.2, 16.3, 4.8 and 9.3 μmol / L, respectively. The IC50 values of reference 2-aminoanthraquinone and 1-naphthol were 771 and 282μmol / L, respectively. Ge-132 had almost no inhibitory effect on cultured cells in vitro. Conclusion The new organic germanium compounds modified by Ge-132 can inhibit the proliferation of cancer cells in vitro.