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作者从1986年10月～1988年2月随机双盲比较了氟康唑和酮康唑治疗获得性免疫缺陷综合症(AIDS)和AIDS-相关复合症状(ARC)患者口咽念珠菌病的疗效和毒性。在37例中经真菌学证实有40次口咽念珠菌感染发作。20次发作(18例患者)每天用50mg氟康唑治疗,20次发作(19例患者)每天用200mg酮康唑治疗。两组均在每天同一时间口服相同的胶囊。两组治疗前的临床特征和实验室检查结果相似,性别、种族及念珠菌病
The authors compared the efficacy of fluconazole and ketoconazole in the treatment of oropharyngeal candidiasis in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) from October 1986 to February 1988. And toxicity. Forty-eight episodes of oropharyngeal candidiasis were confirmed by mycology in 37 cases. 20 episodes (18 patients) were treated with 50 mg fluconazole daily and 20 episodes (19 patients) were treated with 200 mg ketoconazole daily. Both groups orally took the same capsules at the same time each day. The clinical characteristics of the two groups before treatment were similar to those of laboratory tests, and gender, race and candidiasis