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获得遗传学上与患者相配的大量细胞是再生医学的梦想。诱导性多能干细胞技术通过在培养皿中培养细胞来研究发病机理,建立疾病模型,观察疾病的分子机制,并发现新细胞基础的药物。诱导多能干(iPS)细胞从非多能细胞诱导产生,但拥有相似于胚胎干(ES)细胞的多能性,Takahashi等[1-4]首先实现了这个突破,在体外成功表达4个转录因子,即Oct4、Sox2、Klf4和c-Myc,这个步骤不需要卵母细胞。自从发现iPS细
Obtaining genetically large numbers of cells that match patients is a dream of regenerative medicine. Induced pluripotent stem cell technology studies pathogenesis by culturing cells in culture dishes, establishing disease models, observing the molecular mechanisms of disease, and finding new cell-based drugs. Induced pluripotent stem (iPS) cells are induced from non-pluripotent cells but possess pluripotency similar to embryonic stem (ES) cells. Takahashi et al. [1-4] first achieved this breakthrough by successfully expressing four transcripts in vitro Factors, Oct4, Sox2, Klf4 and c-Myc, do not require oocytes in this step. Ips fine since found