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目的探讨乙型肝炎病毒(HBV)基因分型与临床的关系。方法采用HBVS区直接测序法对我院164例江苏、安徽籍患者进行基因分型。结果164例患者中C型97例,B型63例,BC混合型4例。HBeAg阳性116例,B型38/63例(60.31%),C型76/97例(78.35%),HBV DNA≥105124例,B型43/63例(68.25%),C型81/97例(83.51%)。差异有统计学意义(P<0.01)。6个家庭的13例HBV感染者进行HBV分型检测,子女的HBV基因型与母亲相同。14例慢性乙型肝炎患者采用苦参素治疗,以B型效果明显。结论江苏、安徽地区的HBV基因分型以C型为主,其次为B、BC混合型,未见A、D、E、F、G、H基因型。C基因型HBeAg阳性多,HBV DNA定量值高。子女的HBV基因型与其母亲相同。
Objective To investigate the relationship between hepatitis B virus (HBV) genotyping and clinical practice. Methods Direct sequencing using HBVS region of our hospital 164 cases of Jiangsu, Anhui patients genotyping. Results Among 164 patients, 97 were type C, 63 were type B and 4 were mixed with BC. HBeAg positive in 116 cases, B type 38/63 cases (60.31%), C type 76/97 cases (78.35%), HBV DNA≥105124 cases, B type 43/63 cases (68.25%), C type 81/97 cases (83.51%). The difference was statistically significant (P <0.01). HBV genotypes were detected in 13 HBV-infected individuals in 6 families, and their children had the same HBV genotype as their mothers. 14 cases of chronic hepatitis B patients treated with oxymatrine, B-type effect is obvious. Conclusions The genotypes of HBV in Jiangsu and Anhui are mainly C genotype, followed by B and BC genotypes, and no genotypes of A, D, E, F, G and H are found. C genotype HBeAg-positive, high quantitative HBV DNA. Children have the same HBV genotype as their mothers.