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目的:研究抑癌基因PTEN在子宫内膜腺癌组织中的表达及其与预后的关系。方法:采用免疫组化SP法检测103例子宫内膜腺癌病理标本PTEN的表达,并对其中54例患者进行5年随访,对PTEN表达情况与生存率进行相关性分析。结果:①子宫内膜腺癌患者PTEN阳性表达率明显高于健康对照组(χ2=83.96,P<0.001)。②子宫内膜腺癌组织分级G3级、临床分期Ⅲ-Ⅳ期、浸润超过1/2肌层厚度及有淋巴结转移者PTEN阳性表达明显降低。③PTEN阳性率与子宫内膜癌术后5年存活率有关(χ2=7.64,r=0.3521,P<0.01),PTEN高表达者,术后5年存活率也越高。结论:子宫内膜癌患者存在PTEN表达下调,PTEN表达与子宫内膜癌临床病理分级、分期、癌细胞浸润、转移及预后有关;子宫内膜组织PTEN检测对诊断子宫内膜癌并判定其恶性程度和预后具有重要意义。
Objective: To investigate the expression of tumor suppressor gene PTEN in endometrial adenocarcinoma and its relationship with prognosis. Methods: The expression of PTEN in 103 cases of endometrial adenocarcinoma was detected by immunohistochemical SP method. 54 of them were followed up for 5 years. The correlation between the expression of PTEN and the survival rate was analyzed. Results: ① The positive rate of PTEN in endometrial adenocarcinoma was significantly higher than that in healthy controls (χ2 = 83.96, P <0.001). ② The grade of endometrial adenocarcinoma was graded G3, clinical stage Ⅲ-Ⅳ, infiltrated more than 1/2 myometrial thickness and PTEN positive expression was significantly lower in patients with lymph node metastasis. ③ The positive rate of PTEN was related to the 5-year survival rate of endometrial carcinoma (χ2 = 7.64, r = 0.3521, P <0.01). The high PTEN expression was associated with the 5-year survival rate. Conclusion: The expression of PTEN is down-regulated in patients with endometrial carcinoma. The expression of PTEN is related to the clinicopathological grade, stage, invasion, metastasis and prognosis of endometrial carcinoma. PTEN detection of endometrial tissue is helpful to diagnose endometrial carcinoma and determine its malignancy Degree and prognosis of great significance.