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目的 观察生长抑素 (SS)对出血性十二指肠溃疡 2 4h胃内pH的影响及其对消化性溃疡出血的治疗效果。方法 ①十二指肠溃疡出血 16例随机分为SS组 ( 2 5 0 μg ,i.v,后 2 5 0 μg/h静滴 )和奥美拉唑组 ( 40mg ,i.v,后 8mg/h静滴 )行 2 4h胃内pH监测 ;②消化性溃疡活动性出血 (渗血或并血管显露 )随机分为治疗组 3 7例 (SS同上 ,用药到出血停止后 48h)和对照组 46例 (奥美拉唑 40mg,i.v,q12h ,5日 )。结果 ①二组pH平均数和中位数 ,以及 2 3h胃内pH >6 0和pH>7 0百分比间无显著差别。②治疗组止血率 ( 91 9% )显著高于对照组 ( 73 9% ) ,再出血率 ( 11 8% )明显低于对照组( 3 5 3 % )。手术和死亡率二组间无显著差异。结论 生长抑素有效抑制胃酸分泌 ,使出血性十二指肠溃疡达最佳止血胃内pH ;有效控制消化性溃疡的活动性出血而降低再出血。
Objective To observe the effect of somatostatin (SS) on intragastric pH of hemorrhagic duodenal ulcer for 24 hours and its therapeutic effect on hemorrhagic peptic ulcer. Methods ① Duodenal ulcer hemorrhage 16 cases were randomly divided into SS group (250 microg iv, followed by 250 microg / h intravenous) and omeprazole group (40 mg, iv, after 8 mg / h intravenous infusion ) 24 h gastric pH monitoring; ② Peptic ulcer active bleeding (bleeding or vascular exposure) were randomly divided into treatment group 37 cases (SS Ibid, medication to bleeding after 48 h) and control group 46 cases (Austria Meprazole 40mg, iv, q12h, 5th). Results ① There was no significant difference between the mean and median of pH value in the two groups and the intragastric pH value of> 60 and the pH> 70% within 23 h. ② The rate of hemostasis (91 9%) in the treatment group was significantly higher than that in the control group (73 9%), and the rate of rebleeding (11 8%) was significantly lower than that of the control group (35 3%). There was no significant difference between the two groups in surgery and mortality. Conclusion Somatostatin can effectively inhibit gastric acid secretion, hemorrhagic duodenal ulcer reach the best intra-gastric pH; effectively control peptic ulcer active bleeding and reduce rebleeding.