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目的探讨经皮氧分压(TcPO_2)在T2DM合并周围神经病变(DPN)患者的变化及临床意义。方法选取2014年10月至2015年9月于江苏省连云港市第一人民医院内分泌科住院的T2DM患者222例,采用TCM400经皮氧分压检测仪检测50名健康对照(NC)组和222例T2DM患者仰卧位足背TcPO_2值,依据神经传导速度(NCV)将T2DM患者分为DPN组102例和非DNP(NDPN)组120例,分析各组一般临床资料。结果与NC组和NDPN组比较,DPN组仰卧位TcPO_2值降低,与病程、多伦多神经病变评分(TCSS)、HbA_1c、SUA、FPG、NCV呈正相关。与正常TcPO_2组比较,低TcPO_2组DPN患者增加,运动和感觉神经NCV降低。Logistic回归分析显示,TcPO_2是DPN的独立危险因素。结论 DPN患者仰卧位TcPO_2降低,是DPN发生发展的危险因素,可能有助于DPN的早期诊断。
Objective To investigate the changes and clinical significance of percutaneous oxygen pressure (TcPO_2) in patients with T2DM complicated with peripheral neuropathy (DPN). Methods Totally 222 T2DM patients hospitalized in Department of Endocrinology, First People’s Hospital of Lianyungang City, Jiangsu Province from October 2014 to September 2015 were selected and 50 healthy control (NC) and 222 T2DM patients were divided into DPN group (n = 102) and non-DNP group (nDPN group) according to nerve conduction velocity (NCV). The clinical data of each group were analyzed. Results Compared with NC group and NDPN group, the value of TcPO_2 in supine position of DPN group was decreased, which was positively correlated with the course of disease, the score of TCSS, HbA_1c, SUA, FPG and NCV. Compared with normal TcPO_2 group, DPN patients in low TcPO_2 group increased, and motor and sensory nerve NCV decreased. Logistic regression analysis showed that TcPO_2 was an independent risk factor for DPN. Conclusions The decrease of TcPO_2 in the supine position of DPN patients is a risk factor for the development of DPN, which may contribute to the early diagnosis of DPN.