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安徽省卫生防疫站毒理科,1976年11月下旬应用大小藉鼠进行药物毒性试验,2个月后该室的6名工作人员中,连续发生典型的流行性出血热轻、中型各1例。在患者血清学检查中,两例患者EHF特异性抗体效价均有4倍以上增长,其他四人除一人未检外,3人中有一人检出EHF.V.IgG1:40(+)。说明该室工作人员6名中流行性出血热显性感染2例,隐性感染1人。为了查清该点的传染源、感染场所及传布途径,我们对该室现有的47只大白鼠和50只小白鼠解剖取肺组织,经IFA法检测EHF病毒抗原,结果大白鼠阳性11只,阳性率为23.4％,小白鼠为阴性。于此同时用GC—1型空气个体采样器,在气温13～14℃,
Anhui Provincial Health and Epidemic Prevention Station of Toxicology, late November 1976 the size of the use of mice to carry out drug toxicity test, two months later in the room of six staff, the typical occurrence of mild and moderate epidemic hemorrhagic fever in 1 case. In patient serology, EHF-specific antibody titers increased more than four-fold in both patients, with one in three out of four other persons tested for EHF.V.IgG1: 40 (+). It shows that there are 6 cases of epidemic hemorrhagic fever in the room staff and 2 cases of latent infection. In order to identify the source of infection at this point, the place of infection and distribution channels, we dissected lung tissue from 47 existing rats and 50 mice in this room. EHF virus antigens were detected by IFA. Results: 11 rats , The positive rate was 23.4%, mice were negative. At the same time with GC-1-type air sampler, at a temperature of 13 ~ 14 ℃,