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目的 :探讨Graves′甲亢患者在1 31 I治疗前服用抗甲状腺药物 (ATD)及停用ATD不同时间对1 31 I疗效的影响。方法 :对 99例1 31 I治疗的甲亢患者随访一年 (不包括甲亢术后复发及曾行1 31 I治疗的患者 ) ,根据治疗前服用ATD与否分为两组 :未治组与服药组 ,比较1 31 I治疗后甲亢的治愈率 ;对于服用ATD的患者 ,根据1 31 I治疗前停用时间分为 4组 :2周、～ 4周、～ 8周、>8周 ,比较1 31 I治疗后 4组的甲亢治愈率。结果 :未治组与服药组在1 31 I治疗后的甲亢治愈率分别为 89.5 % ,5 7.5 % ,应用Fisher精确检验 ,两组间差异有显著性 (P =0 .0 0 86 3) ;治疗前停用ATD不同时间的 4组甲亢患者 ,其1 31 I治愈率的差别无显著性意义 (P =0 .6 2 7)。结论 :1 31 I治疗前服用ATD可降低1 31 I的治愈率 ,即使1 31 I治疗前停用ATD一段时间 ;对于1 31 I治疗前服用ATD的患者 ,在停药时间≥ 2周的情况下 ,其1 31 I的治愈率并不随着停药时间的延长而升高。
OBJECTIVE: To investigate the effect of anti-thyroid drug (ATD) before 131 I treatment and the effect of 131 I in different time of ATD on Graves’ hyperthyroidism. Methods: One hundred and ninety-three cases of 131 I-treated patients with hyperthyroidism were followed up for one year (excluding postoperative recurrence of hyperthyroidism and 131 I-treated patients), and were divided into two groups according to ATD or not before treatment: Group, comparing the cure rate of hyperthyroidism after treatment with 131 I; patients taking ATD were divided into 4 groups according to their deactivation time before treatment: 2 weeks, ~ 4 weeks, ~ 8 weeks,> 8 weeks, compared with 1 31 I treatment after 4 groups of cure rate of hyperthyroidism. Results: The cure rates of hyperthyroidism in the untreated group and the treated group were 89.5% and 7.57% after treatment with 131I, respectively. Fisher exact test was used to compare the two groups. The difference was significant (P = 0.086 3). There was no significant difference in the cure rate of 131 I between the 4 groups of patients with hyperthyroidism who discontinued ATD at different time points before treatment (P = 0.62 27). Conclusions: The use of ATD before treatment with 131 I reduced the cure rate of 131 I even though ATD was discontinued before 131 I treatment; for patients taking ATD prior to 131 I treatment for more than 2 weeks of withdrawal , The cure rate of 131 I does not increase with the withdrawal time.