幽门螺杆菌(Hp)感染导致慢性胃炎和消化性溃疡,同时与胃肿瘤,如胃腺癌和淋巴瘤有关,但目前其致病机制尚不明了。现在已知细胞凋亡对消化道粘膜细胞的数量发挥重要调节作用,而且越来越多的证据提示Hp感染中存在免疫介导的胃粘膜上皮细胞凋亡。本文目的在于确定Hp是否可以直接诱导胃粘膜上皮细胞凋亡,以及Fas-FasL信号系统在这一细胞死亡过程中的作用。 Infection with Helicobacter pylori (Hp) leads to chronic gastritis and peptic ulcer, and is associated with gastric tumors such as gastric adenocarcinoma and lymphoma, but its pathogenesis is unknown at this time. It is now known that apoptosis plays an important regulatory role in the number of alimentary mucosal cells and there is growing evidence that immune-mediated apoptosis of gastric mucosal epithelial cells exists in Hp infection. The purpose of this paper is to determine whether Hp can directly induce gastric mucosal epithelial cell apoptosis and the role of the Fas-FasL signaling system in this cell death process.