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谷氨酰胺 ( Gln)是循环和体内氨基酸池中含量最丰富的氨基酸 :创伤后机体免疫功能损害与血中谷氨酰胺浓度下降密切相关。单核巨噬细胞是免疫系统的组成部分 ,在免疫反应中起重要作用。研究表明谷氨酰胺是单核巨噬细胞主要的代谢底物 ,通过谷氨酰胺酵解途径 ,为细胞代谢提供能量 ;为细胞合成 DNA和 m RNA提供嘌呤、嘧啶、核苷酸生物合成前体 ;提供氨基葡萄糖 ,GTP和 NAD+合成的氮前体。单核巨噬细胞的免疫功能依赖于谷氨酰胺的含量 ,包括吞噬功能、细胞因子合成和分泌以及抗原提呈等功能。通过特殊的营养支持以增加肌肉和血中 Gln浓度 ,改善应激状态下的免疫功能抑制 ,为临床营养支持治疗可提供有益的途径
Glutamine (Gln) is the most abundant amino acid in circulation and in the body’s amino acid pool: damage to immune function in post-traumatic injury is closely linked to a decrease in glutamine concentration in the blood. Mononuclear macrophages are an integral part of the immune system and play an important role in the immune response. Studies have shown that glutamine is the main metabolic substrate for mononuclear macrophages, which provides energy for cell metabolism through the glutamine glycolysis pathway; and purines, pyrimidines, nucleotide biosynthesis precursors for cellular synthesis of DNA and m RNA Provides nitrogen precursors of glucosamine, GTP and NAD + synthesis. Immune function of mononuclear macrophages depends on the content of glutamine, including phagocytosis, cytokine synthesis and secretion and antigen presentation and other functions. Through special nutritional support to increase muscle and blood levels of Gln, to improve immune function in stress state inhibition, clinical nutritional support for treatment can provide a useful way