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目的观察槐耳颗粒联合FOLFOX4化疗方案对结直肠癌患者的生存质量和免疫功能的影响。方法将76例有化疗指征的结直肠癌术后患者随机分成2组,试验组给于槐耳颗粒+FOLFOX4方案,对照组给予安慰剂+FOLFOX4方案。观察2组患者在治疗前后的生存质量、一般状况和免疫状态的改变。结果试验组和对照组治疗有效率分别为92.1%(35/38)和65.8%(25/38),χ2=7.91,P<0.005;生存质量提高率分别为78.9%(30/38)和31.6%(12/38),χ2=6.33,P<0.05;CD3细胞提高率分别为65.8%(25/38)和23.7%(9/38),χ2=7.96,P<0.005;CD4/CD8比值提高率分别为68.4%(26/38)和28.9%(11/38),χ2=10.53,P<0.005。结论槐耳颗粒可显著改善患者症状和生存质量,提高患者免疫状态。槐耳颗粒联合FOLFOX4方案是治疗结直肠癌的一种新的有效方案,值得进一步推广。
Objective To observe the effect of Huaier granules combined with FOLFOX4 chemotherapy on the quality of life and immune function in patients with colorectal cancer. Methods 76 cases of postoperative patients with chemotherapy indications of colorectal cancer were randomly divided into two groups, the experimental group was given the particles + FOLFOX4 Huai Er program, the control group was given placebo + FOLFOX4 program. The quality of life, general condition and immune status of two groups before and after treatment were observed. Results The effective rates of treatment and control were 92.1% (35/38) and 65.8% (25/38) respectively, χ2 = 7.91, P <0.005. The improvement rates of quality of life were 78.9% (30/38) and 31.6 (12/38), χ2 = 6.33, P <0.05; The rate of CD3 cells improvement was 65.8% (25/38) and 23.7% (9/38) respectively, χ2 = 7.96, Rates were 68.4% (26/38) and 28.9% (11/38) respectively, χ2 = 10.53, P <0.005. Conclusion Huaier particles can significantly improve the patient’s symptoms and quality of life, improve patient immune status. The combination of Huaier granules and FOLFOX4 regimen is a new effective treatment for colorectal cancer and worth further promotion.