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本文在观察20例老年人肝炎后肝硬化糖耐量的同时,利用放射免疫法,检测了各时相血清胰岛素,C-肽含量和胰岛素释放指数,与10例健康老年人作阴性对照,和12例中年人肝炎后肝硬化患者、11例原发性11型糖尿病患者作阳性对照。发现20例老年人肝炎后肝硬化患者有18例糖耐量低下,占90%,伴明显肝原性糖尿病倾向,和健康老年人及中年人肝炎后肝硬化者,有显著性差异(P<0.01和P<0.05);同时发现老年人肝炎后肝硬化组各时相胰岛素含量和C-肽含量大致平行增高,胰岛素释放指数增高,较各对照组各时相分别有不同的差异;老年人肝炎后肝硬化后组有25%的病例呈低胰岛素血症,同时在临床上出现尿糖阳性。
In this paper, 20 elderly patients with post-hepatitis liver cirrhosis tolerance test at the same time, the use of radioimmunoassay to detect the serum insulin, C-peptide content and insulin release index of each phase, with 10 healthy elderly as a negative control, and 12 Cases of middle-aged patients with posthepatitic cirrhosis, 11 cases of primary type 11 diabetes patients as a positive control. Found that 20 cases of elderly patients with posthepatitic cirrhosis, 18 cases of impaired glucose tolerance, accounting for 90%, with significant predisposition to hepatic diabetes, and healthy elderly and middle-aged patients with posthepatitis cirrhosis were significantly different (P < 0.01 and P <0.05). At the same time, it was found that the content of insulin and C-peptide in liver cirrhosis group were generally increased in parallel and the index of insulin release was higher than that in control group Differences; 25% of the elderly patients with posthepatitic cirrhosis were hypoglycemia, and the positive urine sugar appeared clinically.