论文部分内容阅读
目的·· :研究英国成瘾人群中与药物滥用过量中毒死亡有关的美沙酮过量中毒死亡的发生趋势与分布。方法·· :调查和分析英格兰和威尔士1983年 -1992年期间发生的因药物过量中毒死亡人群中美沙酮过量中毒死亡的趋势和分布。数据来源 :英国内务部、英国基本医疗保健处、验尸官和警方的报告。数据由伦敦圣乔治医学院成瘾行为研究中心国家物质滥用死亡研究项目组核对整理。结果·· :10a间共发生药物过量中毒死亡者2326例。其中美沙酮过量中毒死亡的比率为24.7 %(男性25.2 %,女性22.6 %) ,平均死亡年龄为27a±s4.4a,其中25 -34a年龄组的死亡率最高(占48.6%)。美沙酮过量中毒的死亡率在研究开始后的前3a为22.8 % ,1990年 -1992年间增至27.5 %。与其它药物过量中毒死亡病例相比,美沙酮过量中毒死亡有明显的年轻化特征(29比27a,U=58251.5,P<0.01)。美沙酮过量中毒死亡多发生在很难寻求到帮助的非医疗场所 ,例如在当事者本人或其它人家中 (MOR=1.51,95 %可置信区间=1.02,2.22)。结论·· :在25a以下人群中实施美沙酮替代治疗应慎重。美沙酮维持治疗应在管理良好、处方和药物发放可受到监测的诊所实施。
Objectives: To study trends and distribution of deaths from methadone overdoses associated with death from excessive drug abuse in UK addicts. Methods ··: To investigate and analyze the trends and distribution of deaths from methadone overdoses in deaths from over-poisoning in England and Wales from 1983 to 1992. Data sources: British Interior Ministry, Basic Health Care UK, coroner and police report. The data were collated by the National Study on Substance Abuse Death in London’s St George School of Medicine’s Addiction Behavior Research Center. Results: · There were 2326 cases of drug overdose death between the two groups. Methadone overdose poisoning death rate was 24.7% (male 25.2%, female 22.6%), the average age of death was 27a ± s4.4a, of which the highest mortality rate of 25-34a (48.6%). Mortality from methadone overdose was 22.8% in the first 3 years of the study and increased to 27.5% between 1990 and 1992. Compared with other deaths caused by drug overdose, methadone death caused by excessive poisoning was obviously younger (29 vs 27 years, U = 58251.5, P <0.01). Mortality from methadone overdoses occurs mostly in non-medical settings where it is difficult to seek help, such as in the client or other persons (MOR = 1.51, 95% confidence interval = 1.02, 2.22). Conclusions · ·: Meta-methadone replacement therapy should be considered carefully in people below 25 years old. Methadone maintenance treatment should be administered in well-managed clinics where prescription and drug delivery can be monitored.