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目的了解福州地区STD门诊高危人群感染人乳头状瘤病毒的基因类型。方法采用流式荧光杂交技术对990例患者进行HPV基因分型检测。结果 990例患者中共检测出484例阳性,感染率为48.89%,以21岁~30岁所占的比例最高(45.45%)。女性HPV感染率(53.33%)高于男性(46.00%),差异有统计学意义(χ2=4.798,P<0.05)。男性患者以低危型HPV6、HPV11、HPV43感染为主;女性患者以低危型HPV6、HPV11合并高危型HPV16感染为主。与女性患者比较,男性患者高危型HPV基因型检出率较低,低危型HPV基因型检出率较高,差异均有统计学意义(χ2值分别为6.471、8.521,P<0.05)。结论福州地区STD门诊患者以低危型HPV6、HPV11感染为主,尽管就诊患者以单一型感染为主,但仍存在较高的高危型和多重感染,应加强对STD高危人群的HPV检测。
Objective To understand the genotypes of human papillomavirus (HPV) at high risk in STD clinics in Fuzhou. Methods Flow cytometry was used to detect HPV genotypes in 990 patients. Results A total of 484 positive samples were detected in 990 patients, the infection rate was 48.89%, and the highest proportion (45.45%) was between 21 and 30 years old. The prevalence of HPV infection in women was 53.33% higher than that in men (46.00%) (χ2 = 4.798, P <0.05). Male patients with low-risk HPV6, HPV11, HPV43 infection; female patients with low-risk HPV6, HPV11 infection with high-risk HPV16-based. Compared with female patients, the detection rate of high-risk HPV genotypes was lower in male patients, while the detection rate of low-risk HPV genotypes was higher in male patients (χ2 = 6.471, 8.521, P <0.05). Conclusions The STD clinics in Fuzhou area are mainly infected with low-risk HPV6 and HPV11. Although the single-type infection is the main symptom in patients with STD in Fuzhou, there are still high-risk and multiple infections. Therefore, HPV testing should be strengthened in STD high-risk population.