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对羟基苯甘氨酸是合成羟氨苄青霉素(阿莫西林)、头孢羟基苄(欧意)、头孢氯苯(先锋IV)等β-内酰胺类半合成抗生素的主要原料,在有机合成和药物生产中有着广泛的用途。而且,实际上合成这些新型的抗生素必不可少的侧链酸是D-对羟基苯甘氨酸。因此,在这些抗生素世界范围内的大量生产中,中间体D,L-对羟基苯甘氨酸的拆分起着决定性的作用。本文以乙酸丁酸纤维素为膜材料,制备乙酸丁酸纤维素手性固膜,并研究其对D,L-对羟基苯甘氨酸的手性拆分能力。研究显示:当CAB浓度为15%,DMF浓度为20%时,膜具有一定的拆分效果,D,L-对羟基苯甘氨酸对映体的分离因子可以达到1.9,说明膜分离技术有望成为大规模手性拆分非常有潜力的方法之一,具有良好的工业应用前景。
P-hydroxyphenylglycine is the main raw material for the synthesis of β-lactam semisynthetic antibiotics such as amoxicillin (Amoxicillin), cefadroxil (Europaea) and cefalorin (Pioneer IV). In the field of organic synthesis and drug production Has a wide range of uses. Moreover, in fact the side chain acid that is essential for the synthesis of these novel antibiotics is D-p-hydroxyphenylglycine. Therefore, the resolution of the intermediate D, L-p-hydroxyphenylglycine plays a decisive role in the mass production of these antibiotics worldwide. In this paper, cellulose acetate butyrate membrane material preparation of cellulose acetate butyrate film solid chiral, and its D, L-p-hydroxyphenylglycine chiral resolution. The results show that when the concentration of CAB is 15% and the concentration of DMF is 20%, the resolution of the membrane can be achieved. The separation factor of D, L-p-hydroxyphenylglycine enantiomer can reach 1.9, indicating that the membrane separation technology is expected to become large Scale chiral resolution is one of the most promising methods, with good prospects for industrial applications.