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开始治疗重度细菌性感染,常联合应用β内酰胺和氨基配糖甙抗生素,可扩大抗菌谱及减缓抗药性的发生。然而,后者有肾、耳毒性。头孢三嗪是新的第三代头孢菌素,半衰期长,为6～9h。已有报告,每日一次头孢三嗪2.0g,血清浓度可超过对大多数病原菌的最小抑菌浓度,治疗脑膜炎并取得可喜的效果。为比较头孢三嗪与庆大霉素加头孢呋新治疗重度细菌性感染的疗效,105名疑有全身性重度细菌感染的患者,随机分成两组。53人(有33人为肯定的重度感染)接受头孢三嗪2.0g,每日一次。52人(34人为肯定的重度感染)接受庆大霉素,开始1.5mg/kg,后改为80mg,
Start treatment of severe bacterial infections, often combined with β-lactam and aminoglycoside antibiotics, antibacterial spectrum can be expanded and slow the emergence of drug resistance. However, the latter has kidney and ototoxicity. Ceftriaxone is the new third generation cephalosporin, with a long half-life of 6 to 9 hours. It has been reported that ceftriaxone 2.0 g per day, the serum concentration can exceed the minimum inhibitory concentration of most pathogens, the treatment of meningitis and achieve gratifying results. To compare the efficacy of ceftriaxone with gentamycin plus cefuroxime in the treatment of severe bacterial infections, 105 patients with suspected severe systemic bacterial infections were randomly assigned to two groups. Fifty-three (33 confirmed positive infections) received ceftriaxone 2.0 g once daily. 52 (34 confirmed positive infections) received gentamicin, starting at 1.5 mg / kg, later changing to 80 mg,